Please see the Terms of Use for information on how this resource can be used. Most often, an accumulation of mutations in bothoncogenes and tumor suppressor genes is responsible for the development of cancer. Because many cancer cells have mutated and inactive p53 proteins, they cannot suppress the virus and are ultimately killed by it. This animation shows how a genetically modified virus can be used to destroy cancer cells.
Resource content is currently unavailable. The Click & Learn presents different types of genes that, when mutated, contribute to cancer, including oncogenes, tumor suppressor genes, and DNA repair genes. The “Overview Worksheet” provides an introduction to p53 and its role in cancer. Explain how the expression and function of p53 is regulated in the cell. Copyright 2020 QUBES. Listed in Teaching Materials | resource by group HHMI BioInteractive. There are two types of genes that are important in the development and growth of cancers: oncogenes and tumor suppressor genes. mutations in the p53 gene play a role in cancer. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different steps in the treatment. The “Resource Google Folder” link directs to a Google Drive folder of resource documents in the Google Docs format. Students learn about the structure of the protein encoded by p53 and how it normally functions to regulate cell division. Because many cancer cells have mutated and inactive p53 proteins, they cannot suppress the virus and are ultimately killed by it. Researchers should cite this work as follows: This publication belongs to the HHMI BioInteractive group. The accompanying worksheets guide students’ exploration. Efficacy of a Medication for Chronic Myeloid Leukemia.
Efficacy of a Medication for Chronic Myeloid Leukemia, Resistance to a Medication for Chronic Myeloid Leukemia, Mechanism of a Medication for Chronic Myeloid Leukemia. Version 1.0 - published on 01 Jul 2019 doi:10.25334/2884-Q064 - cite this, Licensed under CC Attribution-NonCommercial-NoDerivatives 4.0 International according to these terms.
Using real-time in vivo imaging, we confirmed that hypoxia reporter activity was elevated during the initiation of mutant p53 gastric cancer xenografts. When watching a resource, you will be notified when a new version is released. Please see the Terms of Use for information on how this resource can be used. Check on the status of your correspondences with members of the QUBES team. This animation is a clip from a 2003 Holiday Lecture Series, Learning From Patients: The Science of Medicine. The “Advanced Worksheet” challenges students to explore these ideas in greater depth, including how p53 interacts with other molecules in the cell. We're sorry! Students learn about the structure of the protein encoded by p53 and how it normally functions to regulate cell division. Not all downloadable documents for the resource may be available in this format. Find information on common questions and issues. This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer. The “Advanced Worksheet” challenges students to explore these ideas in greater depth, including how p53 interacts with other molecules in the cell. The Click & Learn presents different types of genes that, when mutated, contribute to cancer, including oncogenes, tumor suppressor genes, and DNA repair genes. The Google Drive folder is set as “View Only”; to save a copy of a document in this folder to your Google Drive, open that document, then select File → “Make a copy.” These documents can be copied, modified, and distributed online following the Terms of Use listed in the “Details” section below, including crediting BioInteractive. One to two 50-minute class periods, depending on the amount of in-class discussion and which worksheet is used. It then explores one tumor suppressor gene, p53, and its role in cancer in more depth. The Click & Learn presents different types of genes that, when mutated, contribute to cancer, including oncogenes, tumor suppressor genes, and DNA repair genes. The accompanying worksheets guide students’ exploration. This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer. The “Overview Worksheet” provides an introduction to p53 and its role in cancer. cell death, cell division, complexing domain, DNA binding domain, Mdm2, proteasome, regulation, transactivation domain, transcription factor, tumor. The animation presents an alternative treatment that uses a genetically modified virus to specifically target cancer cells. The p53 Gene and Cancer By HHMI BioInteractive This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer. When this virus tries to replicate after infecting a normal cell, it is suppressed by the cell’s functioning p53 proteins. It then explores one tumor suppressor gene, p53, and its role in cancer in more depth. Describe the structure-function relationship of each of p53’s domains. This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer. About the Holiday Lectures on Science and BioInteractive.org As part of its mission to strengthen science education, HHMI presents the Holiday Lectures on Science, an annual series that brings the latest developments in a rapidly moving field of research into the classroom. Unbiased genome-wide transcriptome analysis revealed that hypoxia signaling was induced by mutant p53 in 2 gastric cancer cell lines. Powered by HUBzero, a Purdue project, QUBES is supported by the National Science Foundation and other funding agencies, (.bmp, .BMP, .csv, .CSV, .doc, .DOC, .docx, .DOCX, .epg, .EPG, .eps, .EPS, .gif, .GIF, .ico, .ICO, .jpg, .JPG, .jpeg, .JPEG, .key, .KEY, .keynote, .KEYNOTE, .mp4, .MP4, .mp3, .MP3, .m4a, .M4A, .m4v, .M4V, .odg, .ODG, .odp, .ODP, .ods, .ODS, .odt, .ODT, .pdf, .PDF, .png, .PNG, .ppt, .PPT, .pptx, .PPTX, .swf, .SWF, .txt, .TXT, .xcf, .XCF, .xls, .XLS, .xlsx, .XLSX, .svg, .SVG, .php, .css, .zip, .gz, .js, .html, .gdoc, .json, .rmd, .htm, .js, .R, .RData, .tif, .tiff, .swc, .webp, .ipynb, .jp2, .jxr, .RData, .nlogo), https://www.biointeractive.org/classroom-resources/p53-gene-and-cancer.